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基础医学类

病理生理学（Pathophysiology）（第10期）

病理生理学（Pathophysiology）（第10期）

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更新日期：2025/05/15

开课平台	学银在线
开课高校	山西医科大学
开课教师	周鑫、刘清华、郭建红、王锋、刘福、杨艳萍、张杨、牛利、武栗妃、邵莹
学科专业	医学基础医学类

开课时间	2025/02/10 - 2025/08/10
课程周期	26 周
开课状态	开课中
每周学时	-

课程简介

病理生理学( pathophysiology)是研究疾病发生、发展规律及其机制的科学，着重从功能与代谢的角度探讨患病机体的生命活动规律，其任务是揭示疾病的本质，为疾病的防治提供理论依据。病理生理学研究的对象是疾病，研究的目的是疾病防治，因此也是一门重要的临床医学课程，处于临床医学、基础医学和其他生命科学的交汇点，在医学教育和医学研究中发挥着枢纽性作用。

课程大纲

Introduction to Pathophysiology

1.1 教学计划
1.2 视频Video
1.3 课件 PPT
1.4 教材

Chapter 1: Introduction to Disease

2.1 执业医师考试大纲
2.2 健康与疾病的概念 Terminology
2.3 病因学 Etiology
2.4 发病学 Pathogenesis
2.5 疾病的转归 Outcome of Disease
2.6 案例 Case study
2.7 思政案例
2.8 拓展资源 Challenge resource

Chapter 2: Fluid-electrolyte imbalance

3.1 执业医师考试大纲
3.2 正常水钠代谢Sodium and fluid balance
3.3 水钠代谢紊乱Sodium and fluid imbalance
3.4 钾代谢紊乱Potassium dyshomeostasis
3.5 案例Case study
3.6 拓展资源 Challenge resource

Chaper 3: Acid base disturbance

4.1 执业医师考试大纲
4.2 酸碱的自稳态Acid-base disturbances
4.3 酸碱平衡紊乱常用指标 laboratory tests
4.4 单纯型酸碱平衡失调 Simple acid-base disturbance
4.5 混合型酸碱平衡紊乱 Mixed acid-base disturbance
4.6 课件 PPT
4.7 案例 Case study
4.8 思政案例
4.9 拓展资源 Challenge resource

Chaper 4: Hypoxia

5.1 执业医师考试大纲
5.2 视频 Video
5.3 概述 Introduction
5.4 缺氧的原因、分类和血氧变化的特点 Causes and Mechanisms of Hypoxia
5.5 缺氧时机体的功能与代谢变化 Effects of Hypoxia
5.6 课件 PPT
5.7 案例 Case study
5.8 拓展资源 Challenge resource

Chapter 5: Fever

6.1 概述 Overview
6.2 病因和发病机制 Etiology and Pathogenesis
6.3 时相和热代谢特点 Temperature Regulation During Different Stages of Fever
6.4 机体的功能及代谢的变化 Impacts of Fever On The Body
6.5 生物学意义及处理原则 Principles of Treatment
6.6 课件PPT
6.7 案例学习
6.8 思政案例
6.9 思政案例
6.10 教材

Chapter 6: Stress

7.1 概述overview
7.2 应激的发生机制Mechanisms of Stress
7.3 应激时机体功能代谢的变化alterations of metabolism and function
7.4 应激与疾病stress and disease
7.5 应激的防治原则Prevention and treatment of stress
7.6 课件ppt
7.7 病例讨论
7.8 思政案例
7.9 拓展资源challenge resource

Chapter 7: Ischemia reperfusion injury

8.1 执业医师考试大纲
8.2 案例导入case study
8.3 概念conception
8.4 病因和条件Etiology and predisposing conditions
8.5 发生机制pathogenesis
8.6 功能与代谢改变alterations of metabolism and function
8.7 防治原则prevention and treatment
8.8 课件ppt
8.9 病例讨论
8.10 拓展资源
8.11 思政案例

Chapter 8: DIC

9.1 执业医师考试大纲
9.2 正常机体凝血与抗凝血的平衡The regulation of blood coagulation –anticoagulation balance
9.3 DIC
9.4 案例学习 Case study
9.5 参考教材
9.6 课件PPT

Chapter 9: Shock

10.1 执业医师考试大纲
10.2 概念 Concept
10.3 原因与分类 Etiology and classification of shock
10.4 发生机制 Pathogenesis of shock
10.5 细胞代谢、结构改变和器官功能障碍 Alterations of cellar metabolism and structure and impairment of organic function
10.6 防治原则 Prevention and treatment
10.7 案例学习 Case study
10.8 思政案例
10.9 课件 ppt
10.10 参考教材

Chapter 10: Cardiac Dysfunction

11.1 执业医师考试大纲
11.2 概念
11.3 病因、诱因 Etiology
11.4 分类 Classification
11.5 机体代偿适应性反应 The compensatory and adaptive response
11.6 发病机制Pathogenesis of cardiac dysfunction
11.7 临床表现的病理生理基础The pathophysiologic basis of clinical manifestation of cardiac insufficiency
11.8 治疗原则
11.9 病例学习 Case Study
11.10 20241119课件PPT

Chapter 11: Pulmonary dysfunction

12.1 执业医师考试大纲
12.2 概述 Overview
12.3 病因和发病机制 Etiology and Pathogenesis
12.4 功能与代谢变化 Alteration of Function and Metabolism
12.5 ARDS
12.6 COPD
12.7 气胸 Pneumothorax
12.8 防治的病生基础 Pathophysiological Basis of Treatment
12.9 课件PPT
12.10 案例学习
12.11 思政案例

Chapter 12: Hepatic dysfunction

13.1 执业医师考试大纲
13.2 肝功能不全的病因和分类Etiology and Classification
13.3 肝功能不全时机体的功能与代谢变化Manifestations
13.4 肝性脑病Hepatic Encephalopathy
13.5 案例学习Case Study
13.6 思政案例
13.7 拓展资源 Challenge Resources

Chapter 13: Renal dysfunction

14.1 执业医师考试大纲
14.2 概述（overview)
14.3 急性肾损伤（Acute kidney Injury)
14.4 慢性肾疾病（Chronic kidney disease)
14.5 课件PPT
14.6 案例(Case Study)

Chapter 1: Introduction to Pathophysiology and Disease

15.1 Outline &Textbook
15.2 Introduction to Pathophysiology
15.3 Terminology-Introduction to Disease
15.4 Framework for Pathophysilogy--Introduction to Disease
15.5 Discussion
15.6 Case study
15.7 Supplementary resources
15.8 Challenge resources

Chapter 2：Fluid-electrolyte imbalance

16.1 Outline &Textbook
16.2 Sodium and water Balance
16.3 Sodium and water imbalance
16.4 Potassium imbalance
16.5 Quiz
16.6 Case study
16.7 Supplementary resources
16.8 Challenge resources

Chapter 3:acid and base imbalance

17.1 Outline & Textbook
17.2 Objectives
17.3 Acid-base balance and its regulation
17.4 Acid-bases homeostasis
17.5 Parameters of Acid-Base Balance
17.6 Simple Acid-Base Disterbance
17.7 Mixed acid-base disturbances
17.8 quiz
17.9 Case study
17.10 Supplementary resources
17.11 Live Class

Chapter 4:Fever

18.1 Outline & Textbook
18.2 Objectives
18.3 Introduction
18.4 Mechanisms of body temperature control
18.5 Etiology and pathogenesis of fever
18.6 Impacts of fever on body
18.7 Principles of treatment
18.8 Case study
18.9 Supplementary resources
18.10 Challenge resources
18.11 Live Class

Chapter 5 Ischemia-reperfusion injury

19.1 Outline
19.2 The pathogenesis of ischemia-reperfusion injury
19.3 Reactive oxygen
19.4 Calcium overload
19.5 Neutrophils activation
19.6 Alterations of metabolism and function
19.7 Pathophysiological basis of prevention treatment
19.8 Case study
19.9 Quiz
19.10 Reference

Chapter 6: Shock

20.1 Outline
20.2 Introduction
20.3 The pathogenesis of shock
20.4 Alterations of cellular metabolism and impairment of organic function
20.5 Principles of treatment
20.6 Case study
20.7 PPT
20.8 Quiz

Chapter 7: DIC

21.1 Outline
21.2 Normal Coagulation-Anticoagulation Balance
21.3 DIC
21.4 Clinical manifestations
21.5 Stages and types of DIC
21.6 Principles of prevention and treatment of DIC
21.7 Case study
21.8 PPT

Hypoxia

22.1 Outline
22.2 Case Introduction and Question Placement
22.3 Introduction
22.4 Classification, etiology and mechanisms of hypoxia
22.5 Pathophysiological basis of prevention and treatment
22.6 case study
22.7 supplementary resources
22.8 Live class

Chapter 9: Pulmonary Dysfunction

23.1 Outline
23.2 Case Introduction and Question Placement
23.3 Definition and Classification
23.4 Etiology and Pathogenesis
23.5 Alteration of Function and Metabolism
23.6 Pathophysiological basis of prevention and treatment
23.7 Supplementary resources

Chapter 10:Hepatic Dysfunction

24.1 Outline &Textbook
24.2 Hepatic Dysfunction
24.3 Hepatic Encephalopathy
24.4 Quiz
24.5 Case Study
24.6 Supplementary resources

Chapter 11: Cardiac Dysfunction

25.1 Introduction
25.2 Concept of cardiac dysfunction
25.3 Etiology of cardiac dysfunction
25.4 Classification of cardiac dysfunction
25.5 Compensatory and Adaptive response of the body
25.6 The pathogenesis of of cardiac dysfunction
25.7 The clinical manifestations of cardiac dysfunction
25.8 The treat principles
25.9 Case
25.10 Quiz
25.11 Supplementary resources

Chapter 12: Renal dysfunction

26.1 Review
26.2 Acute Kidney Injure
26.3 Chronic Kidney Disease
26.4 Summary
26.5 Case study